Fillers like BOTOX® Cosmetic, Restylane® and JUVÉDERM® injectable gel treat lines and creases within targeted facial areas. These cosmetic fillers replace lost firmness with simple, safe and effective procedures. Men and women turn to cosmetic fillers to improve the appearance of wrinkles and folds on and around the mouth. Cosmetic fillers are also used to combat crow’s feet and furrows in the brow. These types of injected treatments usually last for at least four months, depending on the type of formula used. All cosmetic injections are to be considered temporary.